| 2. Jornada | 14.01.2023 | Atlas Guadalajara [] | - | Santos Laguna [] | 1:3 | ||||
| 3. Jornada | 21.01.2023 | Santos Laguna [] | - | CF Monterrey [] | 3:1 | ||||
| 5. Jornada | 05.02.2023 | Santos Laguna [] | - | Club León [] | 3:0 | ||||
| 6. Jornada | 11.02.2023 | Deportivo Guadalajara [] | - | Santos Laguna [] | 0:0 | ||||
| 7. Jornada | 18.02.2023 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 8. Jornada | 25.02.2023 | Santos Laguna [] | - | Mazatlán FC [] | 2:0 |  |
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| 9. Jornada | 04.03.2023 | UANL Tigres [] | - | Santos Laguna [] | 3:3 | ||||
| 16. Jornada | 22.04.2023 | Atlético San Luis [] | - | Santos Laguna [] | 0:1 | ||||
| 17. Jornada | 29.04.2023 | Club León [] | - | Santos Laguna [] | 3:0 | ||||
| 18. Jornada | 06.05.2023 | Santos Laguna [] | - | Club Tijuana [] | 2:2 |
México