| 1. Jornada | 28.07.2021 | Real Cartagena | - | Valledupar FC | 2:2 | ||||
| 2. Jornada | 03.08.2021 | Boyacá Chicó | - | Real Cartagena | 1:0 | ||||
| 4. Jornada | 14.08.2021 | Real Santander | - | Real Cartagena | 2:2 | ||||
| 10. Jornada | 29.09.2021 | Real Cartagena | - | Llaneros FC | 2:1 | ||||
| 11. Jornada | 06.10.2021 | Tigres FC | - | Real Cartagena | 1:2 | ||||
| 12. Jornada | 12.10.2021 | Real Cartagena | - | Barranquilla FC | 3:1 |
Colombia