| 1. Jornada | 17.03.2021 | Cumbayá | - | Gualaceo SC | 2:1 |  |
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| 2. Jornada | 24.03.2021 | Gualaceo SC | - | Atlético Porteño | 3:0 |  |
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| 3. Jornada | 01.04.2021 | Chacaritas FC | - | Gualaceo SC | 2:0 | |
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| 4. Jornada | 07.04.2021 | Gualaceo SC | - | Guayaquil SC | 2:0 | |
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| 5. Jornada | 14.04.2021 | Independiente Juniors | - | Gualaceo SC | 2:0 | ||||
| 6. Jornada | 21.04.2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:0 | |
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| 7. Jornada | 06.05.2021 | Gualaceo SC | - | El Nacional | 1:0 | |
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| 8. Jornada | 12.05.2021 | Liga de Portoviejo | - | Gualaceo SC | 3:1 | |
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| 9. Jornada | 19.05.2021 | Gualaceo SC | - | América de Quito | 1:1 | |
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| 10. Jornada | 26.05.2021 | Atlético Porteño | - | Gualaceo SC | 3:1 | |
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| 11. Jornada | 02.06.2021 | Gualaceo SC | - | Chacaritas FC | 0:0 | |
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| 13. Jornada | 09.06.2021 | Gualaceo SC | - | Independiente Juniors | 0:0 | |
Brasil
Ecuador