| 1. Jornada | 20.02.2021 | San Francisco FC | - | Atlético Chiriquí | 4:4 |  |
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| 2. Jornada | 27.02.2021 | UD Universitario | - | San Francisco FC | 3:2 | ||||
| 3. Jornada | 06.03.2021 | San Francisco FC | - | Independiente de La Chorrera | 0:1 | ||||
| 4. Jornada | 15.03.2021 | Herrera FC | - | San Francisco FC | 1:0 | ||||
| 5. Jornada | 17.03.2021 | San Francisco FC | - | Veraguas Club Deportivo | 1:2 | ||||
| 6. Jornada | 20.03.2021 | Tauro FC | - | San Francisco FC | 1:0 | ||||
| 7. Jornada | 23.03.2021 | San Francisco FC | - | Plaza Amador | 0:2 | |
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| 8. Jornada | 27.03.2021 | San Francisco FC | - | Deportivo del Este | 2:0 | |
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| 10. Jornada | 10.04.2021 | San Francisco FC | - | Sporting San Miguelito | 2:0 | |
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| 11. Jornada | 15.04.2021 | Árabe Unido | - | San Francisco FC | 1:1 | ||||
| 12. Jornada | 21.04.2021 | Atlético Chiriquí | - | San Francisco FC | 3:0 | ||||
| 13. Jornada | 24.04.2021 | San Francisco FC | - | UD Universitario | 0:0 | ||||
| 14. Jornada | 28.04.2021 | Independiente de La Chorrera | - | San Francisco FC | 2:0 | ||||
| 15. Jornada | 03.05.2021 | San Francisco FC | - | Herrera FC | 0:0 |
Panamá