| 6. Jornada | 09.02.2022 | CSD Municipal | - | Xelaju MC | 2:2 | ||||
| 9. Jornada | 27.02.2022 | Iztapa | - | CSD Municipal | 2:1 | ||||
| 10. Jornada | 03.03.2022 | Antigua GFC | - | CSD Municipal | 1:3 | ||||
| 12. Jornada | 12.03.2022 | CSD Municipal | - | Santa Lucía | 2:1 | ||||
| 13. Jornada | 20.03.2022 | Deportivo Guastatoya | - | CSD Municipal | 1:2 | ||||
| 15. Jornada | 04.04.2022 | Comunicaciones | - | CSD Municipal | 2:0 | ||||
| 14. Jornada | 06.04.2022 | CSD Municipal | - | Sololá FC | 4:0 | ||||
| 16. Jornada | 09.04.2022 | CSD Municipal | - | Deportivo Malacateco | 2:0 |  |
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| 19. Jornada | 13.04.2022 | Cobán Imperial | - | CSD Municipal | 1:1 | ||||
| 22. Jornada | 08.05.2022 | Achuapa | - | CSD Municipal | 0:0 | |
Guatemala