| 1. Jornada | 23.01.2022 | Atlético Junior | - | Patriotas FC | 3:1 |  |
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| 7. Jornada | 17.02.2022 | Independiente Medellín | - | Atlético Junior | 2:0 |  |
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| 8. Jornada | 21.02.2022 | Atlético Junior | - | América de Cali | 1:0 | |
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| 9. Jornada | 27.02.2022 | Deportes Tolima | - | Atlético Junior | 0:2 | ||||
| 10. Jornada | 05.03.2022 | Atlético Junior | - | Unión Magdalena | 3:1 | |
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| 13. Jornada | 31.03.2022 | Millonarios | - | Atlético Junior | 1:0 | ||||
| 14. Jornada | 03.04.2022 | Atlético Junior | - | Alianza Petrolera | 3:1 | |
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| 15. Jornada | 10.04.2022 | Deportivo Cali | - | Atlético Junior | 1:1 | ||||
| 16. Jornada | 17.04.2022 | Atlético Junior | - | Atlético Bucaramanga | 2:0 | ||||
| 18. Jornada | 02.05.2022 | Atlético Junior | - | Envigado FC | 4:0 | ||||
| 19. Jornada | 08.05.2022 | Cortuluá | - | Atlético Junior | 1:0 | ||||
| 20. Jornada | 15.05.2022 | Atlético Junior | - | Jaguares de Córdoba | 2:4 |
Venezuela