| 2. Jornada | 03.04.2021 | Deportes Melipilla | - | Ñublense | 1:1 |  |
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| 3. Jornada | 10.04.2021 | Unión Española | - | Deportes Melipilla | 0:2 |  |
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| 4. Jornada | 16.04.2021 | Deportes Melipilla | - | Palestino | 0:1 | ||||
| 6. Jornada | 03.05.2021 | Deportes Melipilla | - | Universidad Católica | 2:0 | ||||
| 7. Jornada | 09.05.2021 | Santiago Wanderers | - | Deportes Melipilla | 0:3 | ||||
| 8. Jornada | 23.05.2021 | Deportes Melipilla | - | Antofagasta | 1:1 | ||||
| 11. Jornada | 21.07.2021 | Universidad de Chile | - | Deportes Melipilla | 2:0 | |
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| 12. Jornada | 24.07.2021 | Deportes Melipilla | - | Unión La Calera | 3:3 | ||||
| 13. Jornada | 28.07.2021 | Cobresal | - | Deportes Melipilla | 1:1 | ||||
| 14. Jornada | 02.08.2021 | Deportes Melipilla | - | Colo-Colo | 2:4 | ||||
| 16. Jornada | 15.08.2021 | Everton | - | Deportes Melipilla | 1:2 | ||||
| 17. Jornada | 22.08.2021 | Deportes Melipilla | - | Huachipato | 1:2 | ||||
| 21. Jornada | 15.09.2021 | Palestino | - | Deportes Melipilla | 3:1 | ||||
| 22. Jornada | 25.09.2021 | Deportes Melipilla | - | Audax Italiano | 1:1 | ||||
| 23. Jornada | 30.09.2021 | Universidad Católica | - | Deportes Melipilla | 4:0 |
Bolivia