| 1. Jornada | 18.07.2021 | Sport Huancayo | - | FBC Melgar | 0:3 |  |
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| 2. Jornada | 25.07.2021 | FBC Melgar | - | César Vallejo | 1:1 | ||||
| 3. Jornada | 01.08.2021 | Deportivo Binacional | - | FBC Melgar | 1:5 | ||||
| 4. Jornada | 04.08.2021 | FBC Melgar | - | Cusco FC | 2:2 | |
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| 5. Jornada | 09.08.2021 | FBC Melgar | - | Alianza Universidad | 3:0 | ||||
| 6. Jornada | 13.08.2021 | Alianza Atlético | - | FBC Melgar | 3:3 | |
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| 7. Jornada | 17.08.2021 | FBC Melgar | - | Universidad Técnica | 0:1 |  |
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| 8. Jornada | 21.08.2021 | Mannucci | - | FBC Melgar | 1:2 | |
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| 9. Jornada | 27.08.2021 | FBC Melgar | - | Sporting Cristal | 0:1 | ||||
| 10. Jornada | 13.09.2021 | Cienciano | - | FBC Melgar | 0:1 | |
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| 11. Jornada | 18.09.2021 | FBC Melgar | - | Ayacucho FC | 1:1 | ||||
| 12. Jornada | 22.09.2021 | Alianza Lima | - | FBC Melgar | 1:0 | |
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| 13. Jornada | 26.09.2021 | FBC Melgar | - | Sport Boys | 1:0 | ||||
| 14. Jornada | 03.10.2021 | Academia Cantolao | - | FBC Melgar | 0:2 | |
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| 15. Jornada | 17.10.2021 | FBC Melgar | - | Universidad San Martín | 6:0 | |
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| 16. Jornada | 24.10.2021 | Deportivo Municipal | - | FBC Melgar | 1:3 | ||||
| 17. Jornada | 31.10.2021 | FBC Melgar | - | Universitario de Deportes | 1:2 | |
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