| 1. Jornada | 04.07.2022 | Atlético San Luis | - | Club León | 1:2 | ||||
| 2. Jornada | 10.07.2022 | Deportivo Guadalajara | - | Atlético San Luis | 0:1 | ||||
| 3. Jornada | 18.07.2022 | Atlético San Luis | - | CF Monterrey | 0:1 | ||||
| 4. Jornada | 23.07.2022 | Mazatlán FC | - | Atlético San Luis | 1:1 | ||||
| 5. Jornada | 27.07.2022 | Atlético San Luis | - | Cruz Azul | 0:0 | ||||
| 8. Jornada | 12.08.2022 | Gallos Blancos | - | Atlético San Luis | 1:1 | ||||
| 9. Jornada | 19.08.2022 | Atlético San Luis | - | Pumas UNAM | 3:2 | ||||
| 10. Jornada | 22.08.2022 | Atlético San Luis | - | Deportivo Toluca | 1:0 | ||||
| 11. Jornada | 29.08.2022 | Santos Laguna | - | Atlético San Luis | 4:1 | ||||
| 12. Jornada | 02.09.2022 | Atlético San Luis | - | Club Tijuana | 0:0 | ||||
| 13. Jornada | 07.09.2022 | CF América | - | Atlético San Luis | 3:0 |  |
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| 14. Jornada | 12.09.2022 | Atlas Guadalajara | - | Atlético San Luis | 1:3 | ||||
| 15. Jornada | 19.09.2022 | Atlético San Luis | - | CF Pachuca | 1:2 | ||||
| 17. Jornada | 02.10.2022 | Atlético San Luis | - | UANL Tigres | 0:3 |
Ecuador