| 2. Jornada | 12.08.2021 | Olimpia | - | Real España | 1:1 |  |
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| 3. Jornada | 16.08.2021 | Platense | - | Real España | 0:2 | ||||
| 4. Jornada | 22.08.2021 | Real España | - | Real Sociedad | 1:1 | ||||
| 5. Jornada | 26.08.2021 | Real España | - | Lobos UPNFM | 5:3 | ||||
| 8. Jornada | 12.09.2021 | Real España | - | Motagua | 2:1 | ||||
| 10. Jornada | 20.09.2021 | Real España | - | Marathón | 0:1 | ||||
| 11. Jornada | 26.09.2021 | Real Sociedad | - | Real España | 0:4 | ||||
| 12. Jornada | 03.10.2021 | Real España | - | Olimpia | 1:1 | ||||
| 1. Jornada | 21.10.2021 | Real España | - | Victoria | 1:1 | ||||
| 15. Jornada | 25.10.2021 | Lobos UPNFM | - | Real España | 1:2 | |
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| 16. Jornada | 28.10.2021 | Real España | - | Honduras Progreso | 4:1 | ||||
| 17. Jornada | 31.10.2021 | Motagua | - | Real España | 0:1 |
Honduras