| 1. Jornada | 25.01.2016 | Blooming | - | The Strongest | 1:0 |  |
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| 2. Jornada | 29.01.2016 | The Strongest | - | Petrolero de Yacuiba | 2:0 | ||||
| 3. Jornada | 02.02.2016 | The Strongest | - | Universitario de Sucre | 1:0 | |
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| 4. Jornada | 06.02.2016 | Nacional Potosí | - | The Strongest | 2:1 | ||||
| 5. Jornada | 14.02.2016 | The Strongest | - | Bolívar | 2:2 | |
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| 13. Jornada | 24.02.2016 | The Strongest | - | Blooming | 3:2 | ||||
| 7. Jornada | 28.02.2016 | The Strongest | - | Oriente Petrolero | 0:0 | |
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| 8. Jornada | 06.03.2016 | Jorge Wilstermann | - | The Strongest | 1:0 | |
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| 9. Jornada | 13.03.2016 | The Strongest | - | Real Potosí | 3:1 | ||||
| 10. Jornada | 03.04.2016 | Club San José | - | The Strongest | 3:2 | ||||
| 12. Jornada | 17.04.2016 | The Strongest | - | Ciclón | 4:2 | ||||
| 14. Jornada | 24.04.2016 | Universitario de Sucre | - | The Strongest | 2:0 | ||||
| 16. Jornada | 01.05.2016 | Bolívar | - | The Strongest | 1:1 | |
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| 17. Jornada | 06.05.2016 | The Strongest | - | Sport Boys Warnes | 4:0 | ||||
| 19. Jornada | 13.05.2016 | The Strongest | - | Jorge Wilstermann | 2:0 | ||||
| 20. Jornada | 15.05.2016 | The Strongest | - | Club San José | 4:1 |
Uruguay