| 1. Jornada | 24.07.2021 | CF Monterrey [Sub 16] | - | Santos Laguna [Sub 16] | 4:4 | ||||
| 2. Jornada | 31.07.2021 | Deportivo Guadalajara [Sub 16] | - | CF Monterrey [Sub 16] | 2:0 | ||||
| 8. Jornada | 11.09.2021 | Atlético San Luis [Sub 16] | - | CF Monterrey [Sub 16] | 2:1 | ||||
| 10. Jornada | 25.09.2021 | CF Monterrey [Sub 16] | - | Mazatlán FC [Sub 16] | 4:0 |  |
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| 12. Jornada | 09.10.2021 | CF Monterrey [Sub 16] | - | Atlético San Luis [Sub 16] | 3:1 | ||||
| 17. Jornada | 13.11.2021 | CF Monterrey [Sub 16] | - | Club León [Sub 16] | 0:3 | ||||
| 18. Jornada | 20.11.2021 | Club Necaxa [Sub 16] | - | CF Monterrey [Sub 16] | 1:1 |
México