| 10. Jornada | 19.09.2021 | FAS | - | Isidro Metapán | 3:0 |  |
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| 11. Jornada | 26.09.2021 | Isidro Metapán | - | AD Chalatenango | 1:4 | ||||
| 12. Jornada | 02.10.2021 | Atlético Marte | - | Isidro Metapán | 2:0 | ||||
| 13. Jornada | 17.10.2021 | Isidro Metapán | - | Santa Tecla FC | 1:1 | ||||
| 14. Jornada | 21.10.2021 | CD Águila | - | Isidro Metapán | 4:0 | ||||
| 15. Jornada | 24.10.2021 | Isidro Metapán | - | Jocoro FC | 1:1 | ||||
| 16. Jornada | 30.10.2021 | Municipal Limeño | - | Isidro Metapán | 2:2 |  |
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| 19. Jornada | 14.11.2021 | Isidro Metapán | - | Luis Ángel Firpo | 2:1 | |
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| 20. Jornada | 18.11.2021 | Once Municipal | - | Isidro Metapán | 1:1 | ||||
| 21. Jornada | 22.11.2021 | Isidro Metapán | - | FAS | 1:2 | ||||
| 22. Jornada | 27.11.2021 | AD Chalatenango | - | Isidro Metapán | 1:0 |
El Salvador