| 3. Jornada | 07.08.2021 | Puebla FC [Sub 16] | - | CF América [Sub 16] | 3:1 | ||||
| 7. Jornada | 04.09.2021 | Pumas UNAM [Sub 16] | - | Puebla FC [Sub 16] | 3:0 | ||||
| 9. Jornada | 18.09.2021 | FC Juárez [Sub 16] | - | Puebla FC [Sub 16] | 1:3 | ||||
| 10. Jornada | 25.09.2021 | Puebla FC [Sub 16] | - | Deportivo Toluca [Sub 16] | 2:2 | ||||
| 13. Jornada | 16.10.2021 | Puebla FC [Sub 16] | - | Gallos Blancos [Sub 16] | 2:2 | ||||
| 15. Jornada | 30.10.2021 | Puebla FC [Sub 16] | - | FC Juárez [Sub 16] | 2:1 | ||||
| 17. Jornada | 13.11.2021 | CF América [Sub 16] | - | Puebla FC [Sub 16] | 1:1 |
México