| 2. Jornada | 20.07.2022 | Libertad | - | Club Olimpia | 4:2 |  |
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| 8. Jornada | 28.08.2022 | Club Olimpia | - | Resistencia SC | 1:1 | ||||
| 9. Jornada | 04.09.2022 | 12 de Octubre de Itauguá | - | Club Olimpia | 1:3 | ||||
| 14. Jornada | 02.10.2022 | Guaireña FC | - | Club Olimpia | 0:1 | ||||
| 15. Jornada | 06.10.2022 | Club Olimpia | - | Tacuary | 1:0 | ||||
| 16. Jornada | 09.10.2022 | Sportivo Ameliano | - | Club Olimpia | 0:2 | ||||
| 13. Jornada | 13.10.2022 | Club Olimpia | - | Libertad | 1:0 | ||||
| 17. Jornada | 16.10.2022 | Cerro Porteño | - | Club Olimpia | 1:2 |  |
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| 18. Jornada | 23.10.2022 | Club Olimpia | - | General Caballero DJLM | 2:1 | ||||
| 19. Jornada | 27.10.2022 | Resistencia SC | - | Club Olimpia | 1:6 |  |
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| 21. Jornada | 08.11.2022 | Sol de América | - | Club Olimpia | 0:2 | ||||
| 22. Jornada | 12.11.2022 | Club Olimpia | - | Club Nacional | 1:1 |
Paraguay