| 1. Jornada | 14.08.2021 | Mosta FC | - | Birkirkara FC | 0:3 | ||||
| 2. Jornada | 20.08.2021 | Sirens FC | - | Mosta FC | 1:1 | ||||
| 3. Jornada | 11.09.2021 | Mosta FC | - | Hamrun Spartans | 1:2 |  |
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| 4. Jornada | 18.09.2021 | Hibernians FC | - | Mosta FC | 3:2 | ||||
| 6. Jornada | 17.10.2021 | St. Luċija FC | - | Mosta FC | 2:2 | ||||
| 7. Jornada | 23.10.2021 | Mosta FC | - | Floriana FC | 1:1 | ||||
| 8. Jornada | 31.10.2021 | Sliema Wanderers | - | Mosta FC | 2:3 | |
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| 11. Jornada | 04.12.2021 | Mosta FC | - | Gudja United | 0:3 |
Nigeria