| 1. Jornada | 04.04.2022 | Finn Harps | - | Drogheda United | 2:2 | ||||
| 10. Jornada | 15.04.2022 | UC Dublin | - | Drogheda United | 0:2 | ||||
| 11. Jornada | 18.04.2022 | Drogheda United | - | Derry City | 1:1 |  |
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| 12. Jornada | 23.04.2022 | Sligo Rovers | - | Drogheda United | 3:2 | |
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| 13. Jornada | 29.04.2022 | Dundalk FC | - | Drogheda United | 4:1 | |
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| 14. Jornada | 06.05.2022 | Drogheda United | - | St Patrick's Athletic | 0:4 | |
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| 17. Jornada | 23.05.2022 | Drogheda United | - | Shamrock Rovers | 1:0 | |
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| 18. Jornada | 27.05.2022 | Bohemian FC | - | Drogheda United | 1:1 | |
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| 21. Jornada | 24.06.2022 | Drogheda United | - | Sligo Rovers | 0:0 | |
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| 22. Jornada | 01.07.2022 | St Patrick's Athletic | - | Drogheda United | 3:0 | ||||
| 23. Jornada | 08.07.2022 | Drogheda United | - | Dundalk FC | 1:0 | |
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| 24. Jornada | 15.07.2022 | Drogheda United | - | Bohemian FC | 0:1 | ||||
| 29. Jornada | 03.09.2022 | Sligo Rovers | - | Drogheda United | 2:0 | ||||
| 30. Jornada | 09.09.2022 | Drogheda United | - | St Patrick's Athletic | 0:2 | |
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| 31. Jornada | 30.09.2022 | Dundalk FC | - | Drogheda United | 2:0 | |
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| 32. Jornada | 07.10.2022 | Bohemian FC | - | Drogheda United | 0:1 |
Irlanda