| 1. Jornada | 12.12.2020 | Al Mokawloon | - | Zamalek | 0:2 | ||||
| 2. Jornada | 17.12.2020 | Pyramids FC | - | Zamalek | 1:1 | ||||
| 7. Jornada | 12.01.2021 | Al Masry Club | - | Zamalek | 0:1 |  |
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| 10. Jornada | 28.01.2021 | Zamalek | - | Misr lel-Maqasah SC | 4:1 | ||||
| 11. Jornada | 02.02.2021 | Ghazl Al Mehalla | - | Zamalek | 2:1 | ||||
| 12. Jornada | 07.02.2021 | Zamalek | - | Ittihad El Iskandary | 2:0 | ||||
| 13. Jornada | 17.02.2021 | Zamalek | - | Ismaily | 2:1 | ||||
| 14. Jornada | 01.03.2021 | Wadi Degla SC | - | Zamalek | 0:0 | ||||
| 15. Jornada | 11.03.2021 | Zamalek | - | Ceramica Cleopatra | 2:0 | |
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| 4. Jornada | 18.04.2021 | Zamalek | - | Al Ahly SC | 1:2 | |
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| 17. Jornada | 26.04.2021 | Zamalek | - | National Bank SC | 4:1 | ||||
| 18. Jornada | 29.04.2021 | Zamalek | - | Al Mokawloon | 2:2 | ||||
| 19. Jornada | 02.05.2021 | Zamalek | - | Pyramids FC | 1:1 | |
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| 20. Jornada | 06.05.2021 | Zamalek | - | Smouha Sporting Club | 2:1 | ||||
| 21. Jornada | 10.05.2021 | Al Ahly SC | - | Zamalek | 1:1 | |
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| 22. Jornada | 14.05.2021 | Zamalek | - | ENPPI | 3:1 |  |
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| 28. Jornada | 07.08.2021 | Zamalek | - | Ghazl Al Mehalla | 3:0 | ||||
| 31. Jornada | 17.08.2021 | Zamalek | - | Wadi Degla SC | 1:0 | ||||
| 34. Jornada | 27.08.2021 | National Bank SC | - | Zamalek | 1:1 |
Egipto