| 5. Jornada | 22.08.2021 | Xelaju MC | - | CSD Municipal | 0:0 | ||||
| 7. Jornada | 29.08.2021 | Nueva Concepción | - | CSD Municipal | 0:2 | ||||
| 9. Jornada | 11.09.2021 | Comunicaciones | - | CSD Municipal | 2:1 | ||||
| 10. Jornada | 18.09.2021 | CSD Municipal | - | Cobán Imperial | 2:1 | ||||
| 8. Jornada | 29.09.2021 | CSD Municipal | - | Achuapa | 1:0 | ||||
| 12. Jornada | 03.10.2021 | Deportivo Guastatoya | - | CSD Municipal | 1:0 |  |
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| 13. Jornada | 09.10.2021 | CSD Municipal | - | Santa Lucía | 1:1 | ||||
| 11. Jornada | 14.10.2021 | Antigua GFC | - | CSD Municipal | 1:1 | ||||
| 15. Jornada | 23.10.2021 | Iztapa | - | CSD Municipal | 1:0 | ||||
| 16. Jornada | 27.10.2021 | CSD Municipal | - | Xelaju MC | 3:0 | ||||
| 18. Jornada | 06.11.2021 | CSD Municipal | - | Nueva Concepción | 2:0 | ||||
| 19. Jornada | 14.11.2021 | Achuapa | - | CSD Municipal | 0:1 |
Guatemala