| 8. Jornada | 12.09.2021 | Once Municipal | - | FAS | 1:3 | ||||
| 9. Jornada | 16.09.2021 | Isidro Metapán | - | Once Municipal | 0:1 | ||||
| 10. Jornada | 19.09.2021 | Once Municipal | - | Atlético Marte | 0:0 | ||||
| 11. Jornada | 26.09.2021 | Santa Tecla FC | - | Once Municipal | 0:1 |  |
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| 12. Jornada | 03.10.2021 | CD Águila | - | Once Municipal | 1:2 | |
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| 13. Jornada | 17.10.2021 | Once Municipal | - | Jocoro FC | 2:2 | |
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| 15. Jornada | 24.10.2021 | Once Municipal | - | Platense Zacatecoluca | 1:1 | ||||
| 16. Jornada | 30.10.2021 | Once Municipal | - | Alianza | 2:3 | |
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| 17. Jornada | 02.11.2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 18. Jornada | 07.11.2021 | Once Municipal | - | AD Chalatenango | 1:2 | ||||
| 19. Jornada | 14.11.2021 | FAS | - | Once Municipal | 3:2 | ||||
| 20. Jornada | 18.11.2021 | Once Municipal | - | Isidro Metapán | 1:1 | ||||
| 21. Jornada | 21.11.2021 | Atlético Marte | - | Once Municipal | 1:4 | ||||
| 22. Jornada | 27.11.2021 | Once Municipal | - | Santa Tecla FC | 4:3 |  |
El Salvador