| 6. Jornada | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 |  |
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| 5. Jornada | 27.08.2022 | Boston River | - | Fénix | 1:1 | ||||
| 4. Jornada | 04.09.2022 | Cerro Largo | - | Boston River | 1:1 |  |
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| 7. Jornada | 10.09.2022 | Boston River | - | Albion | 1:0 | |
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| 8. Jornada | 15.09.2022 | Nacional | - | Boston River | 1:0 |  |
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| 10. Jornada | 24.09.2022 | Deportivo Maldonado | - | Boston River | 2:1 | ||||
| 11. Jornada | 02.10.2022 | Boston River | - | Rentistas | 3:0 | ||||
| 12. Jornada | 09.10.2022 | Liverpool | - | Boston River | 3:2 | |
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| 13. Jornada | 13.10.2022 | Boston River | - | Peñarol | 2:1 | ||||
| 14. Jornada | 17.10.2022 | Montevideo City Torque | - | Boston River | 0:2 | ||||
| 15. Jornada | 24.10.2022 | Boston River | - | Montevideo Wanderers | 2:2 | |
Uruguay