| 2. Jornada | 09.02.2021 | River Plate | - | Guaraní | 1:4 | ||||
| 3. Jornada | 15.02.2021 | Sol de América | - | River Plate | 1:1 | ||||
| 4. Jornada | 19.02.2021 | River Plate | - | Sportivo Luqueño | 1:0 | ||||
| 6. Jornada | 05.03.2021 | River Plate | - | Guaireña FC | 0:1 |  |
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| 7. Jornada | 10.03.2021 | Cerro Porteño | - | River Plate | 3:0 | ||||
| 8. Jornada | 13.03.2021 | River Plate | - | Club Nacional | 0:0 | ||||
| 9. Jornada | 22.03.2021 | Club Olimpia | - | River Plate | 5:1 | ||||
| 10. Jornada | 02.04.2021 | River Plate | - | 12 de Octubre de Itauguá | 0:2 | ||||
| 14. Jornada | 04.05.2021 | River Plate | - | Libertad | 1:3 | ||||
| 15. Jornada | 10.05.2021 | Guaireña FC | - | River Plate | 0:0 | ||||
| 16. Jornada | 16.05.2021 | River Plate | - | Cerro Porteño | 1:1 | ||||
| 17. Jornada | 24.05.2021 | Club Nacional | - | River Plate | 0:1 |
Paraguay