| 1. Jornada | 01.08.2021 | Managua FC | - | Juventus Managua | 0:1 | ||||
| 2. Jornada | 09.08.2021 | ART Municipal Jalapa | - | Managua FC | 1:1 | ||||
| 3. Jornada | 16.08.2021 | Managua FC | - | Real Estelí FC | 3:0 |  |
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| 4. Jornada | 22.08.2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 5. Jornada | 30.08.2021 | Managua FC | - | Diriangén FC | 1:2 | ||||
| 7. Jornada | 13.09.2021 | UNAN Managua | - | Managua FC | 2:3 | ||||
| 8. Jornada | 20.09.2021 | Managua FC | - | Real Madriz | 1:1 | ||||
| 9. Jornada | 27.09.2021 | CD Walter Ferretti | - | Managua FC | 0:0 | ||||
| 10. Jornada | 02.10.2021 | Juventus Managua | - | Managua FC | 1:3 | ||||
| 11. Jornada | 10.10.2021 | Managua FC | - | ART Municipal Jalapa | 3:0 | |
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| 12. Jornada | 17.10.2021 | Real Estelí FC | - | Managua FC | 1:0 | ||||
| 13. Jornada | 21.10.2021 | Managua FC | - | H&H Export Sébaco | 1:2 | |
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| 15. Jornada | 31.10.2021 | Managua FC | - | UNAN Managua | 3:0 | ||||
| 17. Jornada | 18.11.2021 | Real Madriz | - | Managua FC | 1:3 | |
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| 18. Jornada | 22.11.2021 | Managua FC | - | CD Walter Ferretti | 3:1 |
Honduras