| 2. Jornada | 09.07.2022 | Deportivo Guadalajara [Sub 18] | - | Atlético San Luis [Sub 18] | 3:1 |  |
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| 7. Jornada | 05.08.2022 | Mazatlán FC [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 2:2 | ||||
| 13. Jornada | 07.09.2022 | Club Tijuana [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 1:0 | ||||
| 14. Jornada | 10.09.2022 | Deportivo Guadalajara [Sub 18] | - | Puebla FC [Sub 18] | 1:1 | ||||
| 15. Jornada | 17.09.2022 | CF América [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 0:3 | ||||
| 17. Jornada | 01.10.2022 | Cruz Azul [Sub 18] | - | Deportivo Guadalajara [Sub 18] | 0:4 |
México