| 6. Jornada | 26.08.2021 | Alianza | - | FAS | 1:0 |  |
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| 7. Jornada | 29.08.2021 | Isidro Metapán | - | Alianza | 1:2 | |
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| 5. Jornada | 10.09.2021 | Alianza | - | Once Municipal | 1:0 | ||||
| 8. Jornada | 12.09.2021 | Alianza | - | Atlético Marte | 3:1 |  |
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| 9. Jornada | 16.09.2021 | Santa Tecla FC | - | Alianza | 0:4 | ||||
| 11. Jornada | 25.09.2021 | Jocoro FC | - | Alianza | 3:3 | ||||
| 12. Jornada | 02.10.2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 14. Jornada | 21.10.2021 | Alianza | - | AD Chalatenango | 1:0 | ||||
| 16. Jornada | 30.10.2021 | Once Municipal | - | Alianza | 2:3 | ||||
| 18. Jornada | 06.11.2021 | Alianza | - | Isidro Metapán | 1:0 | |
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| 22. Jornada | 27.11.2021 | Alianza | - | Jocoro FC | 2:0 |
El Salvador