| 1. Jornada | 01.08.2021 | Alianza | - | Municipal Limeño | 4:1 | ||||
| 2. Jornada | 08.08.2021 | Municipal Limeño | - | Luis Ángel Firpo | 1:1 | ||||
| 3. Jornada | 11.08.2021 | Once Municipal | - | Municipal Limeño | 4:1 | ||||
| 7. Jornada | 29.08.2021 | Santa Tecla FC | - | Municipal Limeño | 1:1 | ||||
| 8. Jornada | 12.09.2021 | Municipal Limeño | - | CD Águila | 1:0 | ||||
| 9. Jornada | 15.09.2021 | Jocoro FC | - | Municipal Limeño | 3:1 | ||||
| 10. Jornada | 19.09.2021 | AD Chalatenango | - | Municipal Limeño | 1:1 | ||||
| 11. Jornada | 26.09.2021 | Municipal Limeño | - | Platense Zacatecoluca | 0:1 | ||||
| 12. Jornada | 02.10.2021 | Municipal Limeño | - | Alianza | 0:3 | ||||
| 14. Jornada | 09.10.2021 | Municipal Limeño | - | Once Municipal | 1:1 | ||||
| 13. Jornada | 17.10.2021 | Luis Ángel Firpo | - | Municipal Limeño | 1:1 | ||||
| 15. Jornada | 24.10.2021 | FAS | - | Municipal Limeño | 2:1 | ||||
| 16. Jornada | 30.10.2021 | Municipal Limeño | - | Isidro Metapán | 2:2 | ||||
| 18. Jornada | 07.11.2021 | Municipal Limeño | - | Santa Tecla FC | 1:1 | ||||
| 19. Jornada | 14.11.2021 | CD Águila | - | Municipal Limeño | 2:1 |  |
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| 22. Jornada | 27.11.2021 | Platense Zacatecoluca | - | Municipal Limeño | 0:1 |
El Salvador