| 12. Jornada | 23.10.2021 | FK Senica | - | MFK Ružomberok | 0:2 | ||||
| 13. Jornada | 30.10.2021 | MFK Ružomberok | - | ŠKF Sereď | 3:1 | ||||
| 14. Jornada | 07.11.2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 | ||||
| 15. Jornada | 19.11.2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 16. Jornada | 28.11.2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
| 17. Jornada | 04.12.2021 | MFK Zemplín Michalovce | - | MFK Ružomberok | 0:3 |  |
|||
| 22. Jornada | 26.02.2022 | MFK Ružomberok | - | FK Pohronie | 1:0 |
Eslovaquia