| 1. Jornada | 18.01.2021 | Plaza Colonia | - | Liverpool | 0:0 |  |
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| 2. Jornada | 21.01.2021 | Plaza Colonia | - | Progreso | 0:1 | ||||
| 3. Jornada | 29.01.2021 | Fénix | - | Plaza Colonia | 3:3 | |
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| 4. Jornada | 04.02.2021 | Plaza Colonia | - | CA Cerro | 2:1 | ||||
| 5. Jornada | 07.02.2021 | Defensor Sporting | - | Plaza Colonia | 3:2 | ||||
| 6. Jornada | 10.02.2021 | Plaza Colonia | - | Danubio | 3:0 |  |
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| 7. Jornada | 14.02.2021 | Nacional | - | Plaza Colonia | 1:1 | ||||
| 8. Jornada | 19.02.2021 | Plaza Colonia | - | Boston River | 3:0 | |
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| 10. Jornada | 01.03.2021 | Plaza Colonia | - | Rentistas | 5:0 | |
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| 11. Jornada | 07.03.2021 | Cerro Largo | - | Plaza Colonia | 3:1 | ||||
| 12. Jornada | 12.03.2021 | Plaza Colonia | - | Montevideo Wanderers | 3:0 | |
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| 13. Jornada | 20.03.2021 | Peñarol | - | Plaza Colonia | 1:3 | ||||
| 14. Jornada | 26.03.2021 | Plaza Colonia | - | River Plate | 1:0 | ||||
| 15. Jornada | 29.03.2021 | Montevideo City Torque | - | Plaza Colonia | 2:0 |
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