| 1. Jornada | 24.07.2021 | KV Oostende | - | Sporting Charleroi | 0:3 |  |
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| 2. Jornada | 30.07.2021 | KRC Genk | - | KV Oostende | 3:4 |  |
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| 3. Jornada | 08.08.2021 | KV Oostende | - | Gante | 1:0 | ||||
| 4. Jornada | 14.08.2021 | RFC Seraing | - | KV Oostende | 2:3 | ||||
| 5. Jornada | 20.08.2021 | Standard Liège | - | KV Oostende | 1:0 | |
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| 6. Jornada | 29.08.2021 | KV Oostende | - | SV Zulte Waregem | 0:2 | ||||
| 7. Jornada | 10.09.2021 | Club Brugge KV | - | KV Oostende | 3:0 | ||||
| 8. Jornada | 18.09.2021 | KV Oostende | - | K Beerschot VA | 3:1 | |
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| 9. Jornada | 26.09.2021 | KV Oostende | - | RSC Anderlecht | 2:2 | ||||
| 10. Jornada | 02.10.2021 | Sint-Truidense VV | - | KV Oostende | 1:1 | ||||
| 11. Jornada | 16.10.2021 | KV Oostende | - | Cercle Brugge | 2:1 | ||||
| 12. Jornada | 23.10.2021 | KV Kortrijk | - | KV Oostende | 1:0 | ||||
| 13. Jornada | 29.10.2021 | KV Oostende | - | KV Mechelen | 2:4 | ||||
| 14. Jornada | 05.11.2021 | Oud-Heverlee Leuven | - | KV Oostende | 1:0 | ||||
| 15. Jornada | 21.11.2021 | KV Oostende | - | Union Saint-Gilloise | 1:7 | ||||
| 23. Jornada | 21.01.2022 | KV Oostende | - | Royal Antwerp FC | 1:2 | ||||
| 25. Jornada | 29.01.2022 | Cercle Brugge | - | KV Oostende | 0:1 |
Austria
Croacia