| 1. Jornada | 07.11.2021 | Levadiakos | - | Asteras Vlachioti | 2:1 | ||||
| 2. Jornada | 14.11.2021 | Asteras Vlachioti | - | AS Rhodos | 0:0 | ||||
| 3. Jornada | 20.11.2021 | AO Episkopi | - | Asteras Vlachioti | 0:1 | ||||
| 7. Jornada | 12.12.2021 | Panathinaikos II | - | Asteras Vlachioti | 2:0 | ||||
| 8. Jornada | 15.12.2021 | Asteras Vlachioti | - | AE Karaiskakis | 1:1 |  |
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| 9. Jornada | 19.12.2021 | Ergotelis | - | Asteras Vlachioti | 0:0 | ||||
| 26. Jornada | 26.03.2022 | Asteras Vlachioti | - | Ergotelis | 4:0 | ||||
| 28. Jornada | 03.04.2022 | Diagoras FC | - | Asteras Vlachioti | 2:0 | ||||
| 31. Jornada | 13.04.2022 | Asteras Vlachioti | - | OFI Ierapetra | 4:1 | ||||
| 33. Jornada | 27.04.2022 | Asteras Vlachioti | - | AO Egaleo | 2:1 | ||||
| 34. Jornada | 01.05.2022 | Irodotos | - | Asteras Vlachioti | 2:1 |
Grecia