| 2. Jornada | 30.07.2021 | ŠKF Sereď | - | MFK Ružomberok | 2:3 | ||||
| 4. Jornada | 13.08.2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
| 5. Jornada | 21.08.2021 | MFK Ružomberok | - | Spartak Trnava | 0:0 | ||||
| 6. Jornada | 28.08.2021 | MFK Ružomberok | - | MFK Zemplín Michalovce | 0:0 | ||||
| 7. Jornada | 10.09.2021 | Zlaté Moravce | - | MFK Ružomberok | 2:2 | ||||
| 12. Jornada | 23.10.2021 | FK Senica | - | MFK Ružomberok | 0:2 | ||||
| 13. Jornada | 30.10.2021 | MFK Ružomberok | - | ŠKF Sereď | 3:1 |  |
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| 14. Jornada | 07.11.2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 | ||||
| 15. Jornada | 19.11.2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 16. Jornada | 28.11.2021 | Spartak Trnava | - | MFK Ružomberok | 0:3 | ||||
| 17. Jornada | 04.12.2021 | MFK Zemplín Michalovce | - | MFK Ružomberok | 0:3 | ||||
| 18. Jornada | 11.12.2021 | MFK Ružomberok | - | Zlaté Moravce | 1:1 | ||||
| 19. Jornada | 17.12.2021 | FC DAC 1904 | - | MFK Ružomberok | 0:0 | ||||
| 20. Jornada | 14.02.2022 | MFK Ružomberok | - | MŠK Žilina | 5:1 | |
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| 21. Jornada | 19.02.2022 | Tatran Liptovský Mikuláš | - | MFK Ružomberok | 3:2 | |
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| 22. Jornada | 26.02.2022 | MFK Ružomberok | - | FK Pohronie | 1:0 |  |
Eslovaquia