| 19. Jornada | 13.02.2022 | Makedonija GP | - | GFK Tikvesh | 1:0 | ||||
| 20. Jornada | 20.02.2022 | GFK Tikvesh | - | FK Pelister | 1:0 | ||||
| 21. Jornada | 27.02.2022 | KF Shkupi | - | GFK Tikvesh | 3:2 | ||||
| 22. Jornada | 05.03.2022 | GFK Tikvesh | - | FK Skopje | 3:0 | ||||
| 23. Jornada | 13.03.2022 | KF Shkëndija 79 | - | GFK Tikvesh | 2:1 | ||||
| 24. Jornada | 19.03.2022 | GFK Tikvesh | - | FK AP Brera Strumica | 1:2 | ||||
| 28. Jornada | 17.04.2022 | FK Skopje | - | GFK Tikvesh | 1:2 | ||||
| 29. Jornada | 23.04.2022 | GFK Tikvesh | - | FK Borec | 5:0 | ||||
| 30. Jornada | 01.05.2022 | FK Pelister | - | GFK Tikvesh | 1:1 | ||||
| 31. Jornada | 04.05.2022 | GFK Tikvesh | - | FK Renova | 0:1 | ||||
| 32. Jornada | 08.05.2022 | FK Bregalnica Štip | - | GFK Tikvesh | 1:0 |
Macedonia del Norte