| 1. Jornada | 24.07.2021 | FK Jablonec | - | Baník Ostrava | 1:0 | ||||
| 2. Jornada | 31.07.2021 | FK Mladá Boleslav | - | FK Jablonec | 3:0 | ||||
| 3. Jornada | 08.08.2021 | FK Jablonec | - | Bohemians Praha 1905 | 2:2 | ||||
| 4. Jornada | 15.08.2021 | FK Teplice | - | FK Jablonec | 1:0 | ||||
| 5. Jornada | 22.08.2021 | FK Jablonec | - | 1. FC Slovácko | 1:1 | ||||
| 6. Jornada | 29.08.2021 | Sigma Olomouc | - | FK Jablonec | 4:0 |  |
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| 7. Jornada | 12.09.2021 | FK Jablonec | - | MFK Karviná | 1:0 | ||||
| 9. Jornada | 26.09.2021 | FK Jablonec | - | Slovan Liberec | 0:1 | ||||
| 11. Jornada | 16.10.2021 | FK Jablonec | - | Dynamo České Budějovice | 2:2 |  |
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| 12. Jornada | 24.10.2021 | Viktoria Plzeň | - | FK Jablonec | 5:0 | ||||
| 13. Jornada | 31.10.2021 | FK Jablonec | - | FK Pardubice | 1:1 | ||||
| 14. Jornada | 07.11.2021 | FC Fastav Zlín | - | FK Jablonec | 0:0 | ||||
| 15. Jornada | 21.11.2021 | Slavia Praga | - | FK Jablonec | 5:0 | ||||
| 16. Jornada | 28.11.2021 | FK Jablonec | - | FK Mladá Boleslav | 0:1 | ||||
| 17. Jornada | 05.12.2021 | Bohemians Praha 1905 | - | FK Jablonec | 1:2 | ||||
| 18. Jornada | 12.12.2021 | FK Jablonec | - | FK Teplice | 0:2 | |
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| 19. Jornada | 18.12.2021 | 1. FC Slovácko | - | FK Jablonec | 2:1 |
República Checa