| 1. Jornada | 30.07.2022 | Plaza Colonia | - | Boston River | 1:1 | ||||
| 2. Jornada | 07.08.2022 | Cerrito | - | Boston River | 0:3 | ||||
| 3. Jornada | 12.08.2022 | Boston River | - | River Plate | 1:2 | ||||
| 6. Jornada | 21.08.2022 | Defensor Sporting | - | Boston River | 0:1 |  |
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| 4. Jornada | 04.09.2022 | Cerro Largo | - | Boston River | 1:1 | ||||
| 8. Jornada | 15.09.2022 | Nacional | - | Boston River | 1:0 | ||||
| 9. Jornada | 19.09.2022 | Boston River | - | Danubio | 0:1 | ||||
| 11. Jornada | 02.10.2022 | Boston River | - | Rentistas | 3:0 |  |
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| 12. Jornada | 09.10.2022 | Liverpool | - | Boston River | 3:2 | ||||
| 13. Jornada | 13.10.2022 | Boston River | - | Peñarol | 2:1 | ||||
| 15. Jornada | 24.10.2022 | Boston River | - | Montevideo Wanderers | 2:2 |
Uruguay