| 1. Jornada | 31.08.2016 | Boston River | - | Defensor Sporting | 1:1 | ||||
| 3. Jornada | 11.09.2016 | Defensor Sporting | - | Sud América | 2:0 | ||||
| 7. Jornada | 09.10.2016 | Fénix | - | Defensor Sporting | 3:1 | ||||
| 8. Jornada | 16.10.2016 | Defensor Sporting | - | Liverpool | 1:3 |  |
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| 9. Jornada | 23.10.2016 | Plaza Colonia | - | Defensor Sporting | 0:1 | |
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| 10. Jornada | 29.10.2016 | Rampla Juniors | - | Defensor Sporting | 0:1 | ||||
| 11. Jornada | 12.11.2016 | Villa Española | - | Defensor Sporting | 2:2 | ||||
| 12. Jornada | 20.11.2016 | Defensor Sporting | - | Nacional | 3:2 | |
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| 13. Jornada | 26.11.2016 | Defensor Sporting | - | Danubio | 0:0 | ||||
| 14. Jornada | 04.12.2016 | Defensor Sporting | - | Racing | 2:1 | ||||
| 15. Jornada | 10.12.2016 | Peñarol | - | Defensor Sporting | 0:2 |
Uruguay