| 7. Jornada | 10.09.2021 | Zlaté Moravce | - | MFK Ružomberok | 2:2 | ||||
| 8. Jornada | 18.09.2021 | MFK Ružomberok | - | FC DAC 1904 | 1:2 | ||||
| 3. Jornada | 22.09.2021 | MFK Ružomberok | - | Slovan Bratislava | 1:0 | ||||
| 9. Jornada | 25.09.2021 | MŠK Žilina | - | MFK Ružomberok | 0:2 | ||||
| 10. Jornada | 02.10.2021 | MFK Ružomberok | - | Tatran Liptovský Mikuláš | 4:1 | ||||
| 11. Jornada | 16.10.2021 | FK Pohronie | - | MFK Ružomberok | 2:2 | ||||
| 13. Jornada | 30.10.2021 | MFK Ružomberok | - | ŠKF Sereď | 3:1 | ||||
| 14. Jornada | 07.11.2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 | ||||
| 15. Jornada | 19.11.2021 | MFK Ružomberok | - | AS Trenčín | 3:0 | ||||
| 19. Jornada | 17.12.2021 | FC DAC 1904 | - | MFK Ružomberok | 0:0 | ||||
| 20. Jornada | 14.02.2022 | MFK Ružomberok | - | MŠK Žilina | 5:1 |  |
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| 21. Jornada | 19.02.2022 | Tatran Liptovský Mikuláš | - | MFK Ružomberok | 3:2 | ||||
| 22. Jornada | 26.02.2022 | MFK Ružomberok | - | FK Pohronie | 1:0 |
Eslovaquia