| 1. Jornada | 21.07.2018 | FK Senica | - | Spartak Trnava | 1:0 | ||||
| 2. Jornada | 28.07.2018 | Spartak Trnava | - | Zlaté Moravce | 1:0 | ||||
| 3. Jornada | 04.08.2018 | FK Železiarne Podbrezová | - | Spartak Trnava | 1:0 | ||||
| 5. Jornada | 18.08.2018 | FC Nitra | - | Spartak Trnava | 0:0 | ||||
| 6. Jornada | 26.08.2018 | Spartak Trnava | - | MFK Ružomberok | 0:0 | ||||
| 7. Jornada | 02.09.2018 | AS Trenčín | - | Spartak Trnava | 1:0 | ||||
| 8. Jornada | 15.09.2018 | Spartak Trnava | - | MŠK Žilina | 1:2 |  |
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| 9. Jornada | 23.09.2018 | FC DAC 1904 | - | Spartak Trnava | 3:2 | ||||
| 10. Jornada | 29.09.2018 | Spartak Trnava | - | Slovan Bratislava | 1:2 | ||||
| 12. Jornada | 20.10.2018 | Spartak Trnava | - | FK Senica | 4:1 | ||||
| 13. Jornada | 28.10.2018 | Zlaté Moravce | - | Spartak Trnava | 1:1 | |
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| 14. Jornada | 03.11.2018 | Spartak Trnava | - | FK Železiarne Podbrezová | 2:0 | ||||
| 15. Jornada | 11.11.2018 | MFK Zemplín Michalovce | - | Spartak Trnava | 1:0 | |
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| 16. Jornada | 24.11.2018 | Spartak Trnava | - | FC Nitra | 2:3 | ||||
| 17. Jornada | 02.12.2018 | MFK Ružomberok | - | Spartak Trnava | 3:1 | ||||
| 18. Jornada | 08.12.2018 | Spartak Trnava | - | AS Trenčín | 3:1 |
Eslovaquia