| 1. Jornada | 17.07.2022 | Club Olimpia | - | Guaraní | 2:0 | ||||
| 2. Jornada | 22.07.2022 | Guaraní | - | General Caballero DJLM | 2:1 |  |
|||
| 3. Jornada | 26.07.2022 | Resistencia SC | - | Guaraní | 0:0 | ||||
| 4. Jornada | 01.08.2022 | Guaraní | - | 12 de Octubre de Itauguá | 0:1 | ||||
| 5. Jornada | 07.08.2022 | Sol de América | - | Guaraní | 1:0 | ||||
| 6. Jornada | 15.08.2022 | Guaraní | - | Club Nacional | 1:1 | ||||
| 7. Jornada | 22.08.2022 | Cerro Porteño | - | Guaraní | 1:1 | ||||
| 8. Jornada | 27.08.2022 | Libertad | - | Guaraní | 2:2 |  |
|||
| 9. Jornada | 02.09.2022 | Guaraní | - | Guaireña FC | 2:2 | ||||
| 10. Jornada | 11.09.2022 | Tacuary | - | Guaraní | 2:0 | ||||
| 13. Jornada | 24.09.2022 | General Caballero DJLM | - | Guaraní | 3:0 |  |
|||
| 17. Jornada | 17.10.2022 | Club Nacional | - | Guaraní | 2:0 | ||||
| 18. Jornada | 23.10.2022 | Guaraní | - | Cerro Porteño | 1:2 | ||||
| 19. Jornada | 27.10.2022 | Guaraní | - | Libertad | 1:2 | ||||
| 20. Jornada | 30.10.2022 | Guaireña FC | - | Guaraní | 1:0 | ||||
| 21. Jornada | 06.11.2022 | Guaraní | - | Tacuary | 2:1 | ||||
| 22. Jornada | 13.11.2022 | Sportivo Ameliano | - | Guaraní | 4:2 |
Paraguay