| 8. Jornada | 18.09.2021 | MFK Zemplín Michalovce | - | Zlaté Moravce | 2:1 | ||||
| 10. Jornada | 02.10.2021 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:0 | ||||
| 11. Jornada | 16.10.2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 |  |
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| 12. Jornada | 24.10.2021 | FC DAC 1904 | - | MFK Zemplín Michalovce | 1:0 |  |
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| 13. Jornada | 30.10.2021 | MFK Zemplín Michalovce | - | FK Pohronie | 0:2 | ||||
| 14. Jornada | 05.11.2021 | AS Trenčín | - | MFK Zemplín Michalovce | 4:2 | ||||
| 15. Jornada | 21.11.2021 | MFK Zemplín Michalovce | - | Slovan Bratislava | 1:2 | ||||
| 16. Jornada | 27.11.2021 | Tatran Liptovský Mikuláš | - | MFK Zemplín Michalovce | 0:1 | ||||
| 17. Jornada | 04.12.2021 | MFK Zemplín Michalovce | - | MFK Ružomberok | 0:3 | |
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| 18. Jornada | 10.12.2021 | Spartak Trnava | - | MFK Zemplín Michalovce | 2:0 | ||||
| 19. Jornada | 18.12.2021 | Zlaté Moravce | - | MFK Zemplín Michalovce | 0:1 | |
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| 20. Jornada | 11.02.2022 | MFK Zemplín Michalovce | - | ŠKF Sereď | 0:1 | ||||
| 21. Jornada | 19.02.2022 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:1 | |
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| 22. Jornada | 26.02.2022 | MFK Zemplín Michalovce | - | FK Senica | 0:1 |
Eslovaquia