| 3. Jornada | 13.07.2020 | FC Milsami | - | Speranţa Nisporeni | 3:0 |  |
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| 4. Jornada | 18.07.2020 | Speranţa Nisporeni | - | Dinamo-Auto | 1:2 | ||||
| 5. Jornada | 22.07.2020 | FC Floreşti | - | Speranţa Nisporeni | 1:1 | ||||
| 6. Jornada | 25.07.2020 | Speranţa Nisporeni | - | CS Petrocub | 1:4 | ||||
| 7. Jornada | 31.07.2020 | Dacia Buiucani | - | Speranţa Nisporeni | 0:3 | ||||
| 8. Jornada | 04.08.2020 | FC Codru Lozova | - | Speranţa Nisporeni | 0:1 | |
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| 9. Jornada | 10.09.2020 | Speranţa Nisporeni | - | FC Sfîntul Gheorghe | 0:2 | ||||
| 10. Jornada | 18.09.2020 | Speranţa Nisporeni | - | FC Sheriff | 1:2 | |
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| 13. Jornada | 04.10.2020 | Dinamo-Auto | - | Speranţa Nisporeni | 3:3 | ||||
| 14. Jornada | 16.10.2020 | Speranţa Nisporeni | - | FC Floreşti | 0:0 | ||||
| 15. Jornada | 21.10.2020 | CS Petrocub | - | Speranţa Nisporeni | 2:0 | ||||
| 16. Jornada | 25.10.2020 | Speranţa Nisporeni | - | Dacia Buiucani | 0:0 | |
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| 18. Jornada | 06.11.2020 | FC Sfîntul Gheorghe | - | Speranţa Nisporeni | 1:0 | ||||
| 19. Jornada | 21.11.2020 | FC Sheriff | - | Speranţa Nisporeni | 3:0 | ||||
| 20. Jornada | 25.11.2020 | Speranţa Nisporeni | - | FC Zimbru | 2:2 |
Ucrania