| 1. Jornada | 09.01.2021 | Club Tijuana | - | Pumas UNAM | 0:0 | ||||
| 2. Jornada | 16.01.2021 | FC Juárez | - | Club Tijuana | 0:0 | ||||
| 3. Jornada | 23.01.2021 | Puebla FC | - | Club Tijuana | 0:1 |  |
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| 4. Jornada | 31.01.2021 | Club Tijuana | - | Deportivo Toluca | 3:2 |  |
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| 5. Jornada | 05.02.2021 | Atlético San Luis | - | Club Tijuana | 2:2 | ||||
| 6. Jornada | 13.02.2021 | Club Tijuana | - | Club León | 2:0 | |
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| 7. Jornada | 22.02.2021 | UANL Tigres | - | Club Tijuana | 3:2 | ||||
| 8. Jornada | 01.03.2021 | CF Monterrey | - | Club Tijuana | 1:1 | |
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| 9. Jornada | 04.03.2021 | Club Tijuana | - | CF América | 0:2 | ||||
| 10. Jornada | 09.03.2021 | CF Pachuca | - | Club Tijuana | 2:1 | ||||
| 11. Jornada | 14.03.2021 | Club Tijuana | - | Santos Laguna | 0:1 | ||||
| 12. Jornada | 21.03.2021 | Club Tijuana | - | Gallos Blancos | 3:1 | |
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| 13. Jornada | 04.04.2021 | Atlas Guadalajara | - | Club Tijuana | 1:0 | ||||
| 14. Jornada | 12.04.2021 | Club Tijuana | - | Mazatlán FC | 2:3 | |
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| 15. Jornada | 18.04.2021 | Deportivo Guadalajara | - | Club Tijuana | 2:0 | ||||
| 16. Jornada | 24.04.2021 | Club Tijuana | - | Club Necaxa | 1:0 | ||||
| 17. Jornada | 02.05.2021 | Cruz Azul | - | Club Tijuana | 1:1 |
Colombia