| 1. Jornada | 16.02.2022 | Santa Cruz | - | Deportes Temuco | 1:1 | ||||
| 3. Jornada | 01.03.2022 | Santa Cruz | - | CD Magallanes | 1:2 | ||||
| 4. Jornada | 07.03.2022 | Fernández Vial | - | Santa Cruz | 1:0 |  |
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| 6. Jornada | 24.03.2022 | Santa Cruz | - | Barnechea | 1:1 |  |
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| 7. Jornada | 03.04.2022 | Deportes Iquique | - | Santa Cruz | 2:2 | ||||
| 8. Jornada | 12.04.2022 | Santa Cruz | - | Universidad de Concepción | 0:0 | ||||
| 10. Jornada | 21.04.2022 | Rangers | - | Santa Cruz | 2:1 | ||||
| 11. Jornada | 26.04.2022 | Santa Cruz | - | Deportes Copiapó | 2:2 | ||||
| 13. Jornada | 08.05.2022 | Santa Cruz | - | Recoleta | 1:0 | ||||
| 14. Jornada | 13.05.2022 | Unión San Felipe | - | Santa Cruz | 2:1 | |
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| 16. Jornada | 22.05.2022 | Deportes Melipilla | - | Santa Cruz | 1:0 | ||||
| 5. Jornada | 02.06.2022 | Cobreloa | - | Santa Cruz | 1:0 |
Argentina