| 11. Jornada | 15.10.2021 | Roda JC Kerkrade | - | Jong PSV | 2:2 | ||||
| 12. Jornada | 22.10.2021 | Almere City FC | - | Jong PSV | 3:5 | ||||
| 13. Jornada | 01.11.2021 | Jong PSV | - | AZ Alkmaar (J) | 2:0 | ||||
| 16. Jornada | 19.11.2021 | FC Emmen | - | Jong PSV | 2:0 | ||||
| 15. Jornada | 22.11.2021 | Jong PSV | - | NAC Breda | 0:0 | ||||
| 17. Jornada | 26.11.2021 | MVV | - | Jong PSV | 1:2 | ||||
| 19. Jornada | 10.12.2021 | FC Volendam | - | Jong PSV | 3:2 | ||||
| 20. Jornada | 17.12.2021 | Telstar | - | Jong PSV | 0:0 | ||||
| 22. Jornada | 14.01.2022 | VVV-Venlo | - | Jong PSV | 1:4 | ||||
| 28. Jornada | 25.02.2022 | NAC Breda | - | Jong PSV | 3:1 | ||||
| 27. Jornada | 14.03.2022 | FC Den Bosch | - | Jong PSV | 3:2 | ||||
| 32. Jornada | 04.04.2022 | Jong PSV | - | FC Volendam | 2:2 | ||||
| 36. Jornada | 25.04.2022 | Jong PSV | - | MVV | 2:2 |
Bélgica