| 3. Jornada | 07.08.2021 | Puebla FC [Sub 16] | - | CF América [Sub 16] | 3:1 | ||||
| 4. Jornada | 14.08.2021 | CF América [Sub 16] | - | CF Pachuca [Sub 16] | 0:1 | ||||
| 10. Jornada | 25.09.2021 | Gallos Blancos [Sub 16] | - | CF América [Sub 16] | 1:2 | ||||
| 14. Jornada | 23.10.2021 | Cruz Azul [Sub 16] | - | CF América [Sub 16] | 2:2 | ||||
| 16. Jornada | 06.11.2021 | CF Pachuca [Sub 16] | - | CF América [Sub 16] | 3:1 | ||||
| 17. Jornada | 13.11.2021 | CF América [Sub 16] | - | Puebla FC [Sub 16] | 1:1 | ||||
| 18. Jornada | 20.11.2021 | FC Juárez [Sub 16] | - | CF América [Sub 16] | 2:0 |
México