| 1. Jornada | 04.04.2021 | Deportes Iquique | - | Coquimbo Unido | 2:3 | ||||
| 3. Jornada | 25.04.2021 | Deportes Iquique | - | San Marcos | 1:2 | ||||
| 4. Jornada | 03.05.2021 | Barnechea | - | Deportes Iquique | 3:1 |  |
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| 14. Jornada | 07.08.2021 | Deportes Iquique | - | Deportes Temuco | 2:2 |  |
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| 15. Jornada | 15.08.2021 | Puerto Montt | - | Deportes Iquique | 0:0 | ||||
| 16. Jornada | 24.08.2021 | Coquimbo Unido | - | Deportes Iquique | 3:1 | ||||
| 17. Jornada | 29.08.2021 | Deportes Iquique | - | Fernández Vial | 1:3 | ||||
| 18. Jornada | 02.09.2021 | San Marcos | - | Deportes Iquique | 4:2 | ||||
| 19. Jornada | 05.09.2021 | Deportes Iquique | - | Barnechea | 4:2 | ||||
| 20. Jornada | 16.09.2021 | San Luis | - | Deportes Iquique | 1:1 | ||||
| 21. Jornada | 23.09.2021 | Deportes Iquique | - | Deportes Copiapó | 2:1 | ||||
| 22. Jornada | 27.09.2021 | CD Magallanes | - | Deportes Iquique | 2:2 | |
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| 24. Jornada | 08.10.2021 | Universidad de Concepción | - | Deportes Iquique | 3:1 | ||||
| 25. Jornada | 13.10.2021 | Deportes Iquique | - | Cobreloa | 1:0 |
Chile