| 5. Jornada | 03.10.2021 | Anorthosis Famagusta | - | APOEL Nikosia | 2:1 | ||||
| 7. Jornada | 25.10.2021 | Anorthosis Famagusta | - | AEK Larnaca | 1:2 | ||||
| 9. Jornada | 07.11.2021 | Anorthosis Famagusta | - | Paphos FC | 1:0 | ||||
| 11. Jornada | 29.11.2021 | Anorthosis Famagusta | - | Apollon Limassol | 1:1 | ||||
| 12. Jornada | 04.12.2021 | Anorthosis Famagusta | - | PAEEK | 2:3 |  |
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| 1. Jornada | 22.12.2021 | PAEEK | - | Anorthosis Famagusta | 0:2 | ||||
| 17. Jornada | 16.01.2022 | Anorthosis Famagusta | - | AEL Limassol | 2:1 | ||||
| 18. Jornada | 24.01.2022 | AEK Larnaca | - | Anorthosis Famagusta | 1:1 | ||||
| 19. Jornada | 29.01.2022 | Anorthosis Famagusta | - | Omonia Nikosia | 1:1 | |
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| 20. Jornada | 06.02.2022 | Paphos FC | - | Anorthosis Famagusta | 1:1 | ||||
| 15. Jornada | 10.02.2022 | Anorthosis Famagusta | - | Aris Limassol | 3:1 | ||||
| 16. Jornada | 17.02.2022 | APOEL Nikosia | - | Anorthosis Famagusta | 0:2 | ||||
| 22. Jornada | 26.02.2022 | Apollon Limassol | - | Anorthosis Famagusta | 2:2 |
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