| 1. Jornada | 01.08.2021 | Managua FC | - | Juventus Managua | 0:1 | ||||
| 2. Jornada | 09.08.2021 | ART Municipal Jalapa | - | Managua FC | 1:1 | ||||
| 3. Jornada | 16.08.2021 | Managua FC | - | Real Estelí FC | 3:0 | ||||
| 11. Jornada | 10.10.2021 | Managua FC | - | ART Municipal Jalapa | 3:0 | ||||
| 12. Jornada | 17.10.2021 | Real Estelí FC | - | Managua FC | 1:0 | ||||
| 13. Jornada | 21.10.2021 | Managua FC | - | H&H Export Sébaco | 1:2 | ||||
| 14. Jornada | 25.10.2021 | Diriangén FC | - | Managua FC | 0:3 | ||||
| 15. Jornada | 31.10.2021 | Managua FC | - | UNAN Managua | 3:0 | ||||
| 18. Jornada | 22.11.2021 | Managua FC | - | CD Walter Ferretti | 3:1 |
Nicaragua