| 15. Jornada | 05.11.2021 | Chindia Târgoviște | - | Gaz Metan Mediaş | 0:1 | ||||
| 16. Jornada | 22.11.2021 | CS Mioveni | - | Gaz Metan Mediaş | 1:0 |  |
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| 17. Jornada | 29.11.2021 | Gaz Metan Mediaş | - | Farul Constanța | 1:1 | ||||
| 18. Jornada | 06.12.2021 | Argeș Pitești | - | Gaz Metan Mediaş | 1:2 | ||||
| 19. Jornada | 11.12.2021 | Gaz Metan Mediaş | - | FCSB | 0:1 | ||||
| 20. Jornada | 15.12.2021 | FC Botoşani | - | Gaz Metan Mediaş | 2:1 | ||||
| 21. Jornada | 18.12.2021 | Gaz Metan Mediaş | - | CS Universitatea Craiova | 1:1 | ||||
| 22. Jornada | 23.01.2022 | UTA Arad | - | Gaz Metan Mediaş | 0:1 | ||||
| 23. Jornada | 29.01.2022 | FC Voluntari | - | Gaz Metan Mediaş | 3:1 | ||||
| 24. Jornada | 04.02.2022 | Gaz Metan Mediaş | - | Rapid Bucureşti | 1:1 | ||||
| 25. Jornada | 08.02.2022 | Sepsi OSK | - | Gaz Metan Mediaş | 2:0 | ||||
| 26. Jornada | 12.02.2022 | Gaz Metan Mediaş | - | CFR Cluj | 1:2 | ||||
| 27. Jornada | 18.02.2022 | Dinamo Bucureşti | - | Gaz Metan Mediaş | 4:0 |
Rumania