| 21. Jornada | 29.01.2022 | NK Osijek | - | Slaven Belupo | 1:2 |  |
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| 22. Jornada | 06.02.2022 | Hrvatski Dragovoljac | - | NK Osijek | 1:3 | |
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| 23. Jornada | 13.02.2022 | NK Osijek | - | HNK Rijeka | 1:0 | ||||
| 24. Jornada | 19.02.2022 | NK Istra 1961 | - | NK Osijek | 2:3 | |
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| 25. Jornada | 27.02.2022 | NK Osijek | - | Dinamo Zagreb | 1:0 | ||||
| 26. Jornada | 04.03.2022 | Lokomotiva Zagreb | - | NK Osijek | 0:0 | ||||
| 28. Jornada | 20.03.2022 | HNK Šibenik | - | NK Osijek | 0:3 | ||||
| 29. Jornada | 03.04.2022 | NK Osijek | - | Hajduk Split | 0:0 | |
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| 30. Jornada | 10.04.2022 | Slaven Belupo | - | NK Osijek | 0:1 | |
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| 32. Jornada | 23.04.2022 | HNK Rijeka | - | NK Osijek | 3:1 | ||||
| 33. Jornada | 01.05.2022 | NK Osijek | - | NK Istra 1961 | 2:2 | |
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| 35. Jornada | 15.05.2022 | NK Osijek | - | Lokomotiva Zagreb | 1:0 | ||||
| 36. Jornada | 21.05.2022 | HNK Gorica | - | NK Osijek | 1:1 |
Croacia