| 1. Jornada | 25.07.2021 | MFK Zemplín Michalovce | - | FC DAC 1904 | 4:1 | ||||
| 2. Jornada | 31.07.2021 | FK Pohronie | - | MFK Zemplín Michalovce | 2:0 |  |
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| 3. Jornada | 07.08.2021 | MFK Zemplín Michalovce | - | AS Trenčín | 1:2 | ||||
| 5. Jornada | 21.08.2021 | MFK Zemplín Michalovce | - | Tatran Liptovský Mikuláš | 2:1 | ||||
| 6. Jornada | 28.08.2021 | MFK Ružomberok | - | MFK Zemplín Michalovce | 0:0 | ||||
| 7. Jornada | 11.09.2021 | MFK Zemplín Michalovce | - | Spartak Trnava | 1:2 | ||||
| 10. Jornada | 02.10.2021 | MFK Zemplín Michalovce | - | MŠK Žilina | 1:0 | ||||
| 11. Jornada | 16.10.2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 12. Jornada | 24.10.2021 | FC DAC 1904 | - | MFK Zemplín Michalovce | 1:0 | ||||
| 13. Jornada | 30.10.2021 | MFK Zemplín Michalovce | - | FK Pohronie | 0:2 | ||||
| 14. Jornada | 05.11.2021 | AS Trenčín | - | MFK Zemplín Michalovce | 4:2 |
Eslovaquia